A pneumonia outbreak associated with a new coronavirus of probable bat origin.

Nature. 2020 Feb 3. doi: 10.1038/s41586-020-2012-7.

A pneumonia outbreak associated with a new coronavirus of probable bat origin.

  1. Zhou P1, Yang XL1, Wang XG2, Hu B1, Zhang L1, Zhang W1, Si HR1,3, Zhu Y1, Li B1, Huang CL2, Chen HD2, Chen J1,3, Luo Y1,3, Guo H1,3, Jiang RD1,3, Liu MQ1,3, Chen Y1,3, Shen XR1,3, Wang X1,3, Zheng XS1,3, Zhao K1,3, Chen QJ1, Deng F1, Liu LL4, Yan B1, Zhan FX4, Wang YY1, Xiao GF1, Shi ZL5.

Author information Abstract Since the SARS outbreak 18 years ago, a large number of severe acute respiratory syndrome-related coronaviruses (SARSr-CoV) have been discovered in their natural reservoir host, bats1-4. Previous studies indicated that some of those bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a novel coronavirus (2019-nCoV) which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started from 12 December 2019, has caused 2,050 laboratory-confirmed infections with 56 fatal cases by 26 January 2020. Full-length genome sequences were obtained from five patients at the early stage of the outbreak. They are almost identical to each other and share 79.5% sequence identify to SARS-CoV. Furthermore, it was found that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. The pairwise protein sequence analysis of seven conserved non-structural proteins show that this virus belongs to the species of SARSr-CoV. The 2019-nCoV virus was then isolated from the bronchoalveolar lavage fluid of a critically ill patient, which can be neutralized by sera from several patients. Importantly, we have confirmed that this novel CoV uses the same cell entry receptor, ACE2, as SARS-CoV.

  1. Calling all coronavirus researchers: keep sharing, stay open. [Nature. 2020]Comment in

  2. PMID: 32015507 DOI: 10.1038/s41586-020-2012-7

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